Jaising also argued the case of Githa Hariharan, in which the Supreme Court decided that a mother is equally a natural guardian of a child as a father.

"[12] Jaising has represented the victims of the Bhopal tragedy in the Supreme Court of India in their claim for compensation against the Union Carbide Corporation.

Jaising has been associated with several Peoples Commissions on Violence in Punjab to investigate the extrajudicial killings, disappearances, and mass cremations that took place during the period 1979 to 1990.

The United Nations appointed Jaising to a fact-finding mission investigating the alleged murder, rape and torture by security forces against Rohingya Muslims in Myanmar's Rakhine state.

She later became the founder secretary of the Lawyers Collective, an organization that provides legal funding for the underprivileged sections of Indian society.

[15] She founded a monthly magazine called The Lawyers, in 1986, which focuses on social justice and women's issues in the context of Indian law.

She has been involved in cases related to discrimination against women, the Muslim Personal Law, the rights of pavement dwellers and the homeless and the Bhopal gas tragedy.

She was conferred with the Rotary Manav Seva Award in recognition of her services to the nation in fighting corruption and as a champion of the weaker sections of the society.