Indrajith made his acting debut in the 1986 film Padayani as a child artist, and has gone on to star in more than 90 films, notably Meesa Madhavan (2002), Runway (2004), Vesham (2004), Classmates (2006), Chotta Mumbai (2007), Arabikkatha (2007), Twenty:20 (2008), Nayakan (2010), Karayilekku Oru Kadal Dooram (2010), Ee Adutha Kaalathu (2012), Amen (2013), Left Right Left (2013), Ezhamathe Varavu (2013), Angels (2014), Amar Akbar Anthony (2015), Virus (2019), Lucifer (2019), Halal Love Story (2020) and Kurup (2021).

Indrajith has also starred in a few Tamil, English, Telugu and Hindi films, such as En Mana Vaanil (2002), Before the Rains (2007), Sarvam (2009), Kavya's Diary (2009), and The Waiting Room (2010).

He was noted for his villain role Eappen Pappachi in the blockbuster Meesa Madhavan, directed by Lal Jose.

He acted alongside Mohanlal in Anwar Rasheed's Chotta Mumbai and Shaji Kailas's Baba Kalyani.

[4][5] He starred in the lead role with Vineeth in Hariharan's Film Ezhamathe Varavu, written by M. T. Vasudevan Nair after the success of Pazhassi Raja (2009).