Indranee made her political debut in the 2001 general election as part of a six-member PAP team contesting in Tanjong Pagar GRC and won.

After the death of Minister Mentor Lee Kuan Yew on 23 March 2015, Indranee served as the MP for the Tanjong Pagar–Tiong Bahru ward concurrently until the 2015 general election as no by-elections were called due to it being a group representation constituency (GRC).

[4] Indranee led a 12-member committee in 2013 to provide a strategic direction for the planned third law school in Singapore, including its admissions criteria, curriculum development and educational philosophy.

[7] On 9 March 2018, Indranee criticised Workers' Party Member of Parliament Sylvia Lim on Facebook after the latter voiced her suspicion on the government's intention to raise the GST in order to extract an apology.

[10] Indranee is the daughter of A. T. Rajah, a former Deputy Commissioner of Police and former President of the Singapore National Olympic Council.