De Vroome has won seven singles and six doubles titles on the ITF Women's Circuit.

De Vroome was awarded a wildcard to compete in the qualifying draw of the 2012 Miami Open, but she lost in the first round to Sloane Stephens.

[1][2] De Vroome made her debut at a Grand Slam qualifying event in May 2014 at the French Open, defeating former top-30 player Kateryna Bondarenko in straight sets in the first round,[3] but was defeated in round two by third seed Tímea Babos.

[4] At the Diamond Games in February 2015, she achieved her first WTA Tour main-draw match-win by defeating Tsvetana Pironkova in the first round.

[5] De Vroome did not play competitive tennis from the summer of 2016 until October 2018 due to Lyme disease.