[7] Assigned male at birth, Indya Moore is a Bronx native of Haitian, Puerto Rican, and Dominican ancestry.

[10] They began working as a model at the age of 15, and eventually earned their General Equivalency Diploma (GED).

[10][11] Moore became a model at the age of 15, and began working shoots for Dior and Gucci, despite the fashion industry's initial treatment of them as a risky choice.

[10] Although Moore was booking modeling gigs, they became increasingly disenchanted with the fashion industry and its emphasis on body image.

[26] Moore also started the production company Beetlefruit Media, which provides a platform for stories about disenfranchised groups.

[29] In December 2019, Moore debuted as the voice of Shep on the animated limited series Steven Universe Future.

[34][35] Moore voices the character Brooklyn, one of Lunella's classmates, in Moon Girl and Devil Dinosaur.

[36][37] Moore will appear in the upcoming horror television series, Magic Hour, a gender-bending recreation of Mary Shelley's Frankenstein, directed by Che Grayson and filmed in Tokyo, on which they also serve as an executive producer.

[7] Moore has spoken openly about their lifelong struggles with the bullying and transphobia that caused them to leave home at 14 and drop out of school in the 10th grade.