[1] She was the daughter of Infante Francisco de Paula of Spain, the third surviving son of King Charles IV of Spain, and Princess Luisa Carlotta of the Two Sicilies, daughter of King Francis I of the Two Sicilies.

Instead of marrying a prince of a European royal house, she married the Spanish aristocrat Don José María Osorio de Moscoso y Carvajal, Duke of Sessa in 1847.

She was an intimate friend and favorite of her cousin and sister-in-law Queen Isabella II, who allowed her marriage despite the unprecedented unequal rank.

The couple supported the monarchy after the Revolution of 1868, sending financial aid to the dethroned Crown, considerably reducing their income and even having to sell some properties, such as the Altamira Palace, as well as the Villamanrique Palace, in the town of the same name, in addition to others.

This did not prevent the Infanta from leading a high standard of living, traveling regularly between Madrid, Paris and Biarritz.