María Josefa Carmela of Spain (6 July 1744 – 8 December 1801) was a Princess of Naples and Sicily by birth.

Her parents' fourth child, at the time of her birth she had an older sister María Isabel Ana (1743–1749).

Her parents were a devoted couple; her mother Maria Amalia of Saxony died barely a year after the family's arrival to Spain.

After the death of her father, she continued living in the Royal Palace with her brother Charles IV.

[1] She died at the Royal Palace of Madrid aged 57, before her brother Charles IV lost the throne and was exiled in 1808.