Infanta Maria of Guimarães (12 August 1538 – 9 July 1577) was a Portuguese infanta, daughter of Infante Duarte, Duke of Guimarães (son of King Manuel I of Portugal), and Isabel of Braganza.
She married Alessandro Farnese, Duke of Parma and Piacenza on 11 November 1565.
She was Hereditary Princess of Parma by marriage.
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