Infante Carlos of Spain (15 September 1607 – 30 July 1632), was the second son of King Philip III of Spain and his queen consort, Margaret of Austria.

Infante Carlos was the younger brother of Philip IV, and, as long as the King remained childless, was heir to the Spanish throne.

Contemporaries described Infante Carlos as prudent and liberal and he seemed to have been a "vigilant observer of royal customs".

[1] Other than his brother Fernando, who was assigned a role at an early age, he remained in a child-like position until his mid-twenties.

Francisco de Quevedo dedicated a sonnet entitled The Burial of the Most Serene Infante Don Carlos to this event.