[1] It is situated between the base of the transverse process of the last cervical vertebra and the neck of the first rib, on the medial side of the costocervical artery.

As the sympathetic trunk curves posteriorly between the neck and thorax, this ganglion is oriented in a nearly anteroposterior axis.

[citation needed] The ganglion is situated posterior to the commencement of the vertebral artery.

The posterior cord typically splits to surround the vertebral artery; the anterior cord loops around the subclavian artery, forming the ansa subclavia.

[3] The inferior cervical ganglion gives off two branches:[citation needed] It is probably formed by the coalescence of two ganglia which correspond to the seventh and eighth cervical nerves.