Continuing the story of the Rexxon-Terran conflict from the game Epic, Inferno charts the adventures of a Terran pilot as he seeks revenge on the Rexxons, who had genetically altered him to become one of their own.

[5] The game was released in winter of 1994 on CD-ROM only; Inferno came with comic book that documented the story of the player's character, written by sometime 2000 AD contributor Sean Phillips.

PC Gamer however criticized the game's complex controls, but noted Inferno as a "state of the art" space opera shoot 'em up, despite having significant competition in the genre.

He also commented that although it doesn’t have the charm like Wing Commander, In comparison he stated that Inferno has: "Far better 3D effects, a widely variable mission plan and wicked fast gameplay.

[12] In 1996, CGW ranked it as the 44th worst game of all time, summarizing it as having a "Bad storyline, guttural voice acting, and way too many dull cinematics in a limp space shooter.