Created by Roy Thomas, Jerry Ordway, and Mike Machlan, Infinity, Inc. first appears in All-Star Squadron #25 (September 1983).

Artists who worked on the series included Jerry Ordway, Don Newton, Todd McFarlane, Michael Bair and Vince Argondezzi.

The series ended in 1988 with the death of the Star-Spangled Kid (by then known as Skyman) at the hands of Solomon Grundy, and the group presumably disbanded shortly thereafter.

Several members of Infinity, Inc. went on to supporting roles in other comic series: Fury filled a pivotal role in The Sandman and is the mother of Daniel Hall, while Hourman, Obsidian, Nuklon (as Atom Smasher), Silver Scarab (as Doctor Fate), and Power Girl joined the 21st century incarnation of the JSA.

The series originally took place on the parallel world of Earth-Two, but in 1986 it was merged with the rest of DC continuity following Crisis on Infinite Earths.

Hector Hall, Lyta Trevor, Norda Cantrell, and Albert Rothstein decide to adopt identities of their own and apply for membership in the Justice Society of America (JSA).

Star-Spangled Kid decides to leave the JSA to create a new group and they are joined by Power Girl, Huntress, and Brainwave Jr.

[6] In a press conference to garner media attention for the new team, the members publicly divulge their secret identities, and Hector announces his engagement to Lyta.

Star-Spangled Kid forms a partnership with Los Angeles to commission his team as for-hire protectors and purchases Stellar Studios to revitalize its production of movies.

[7] Fury is kidnapped in an extortion attempt by the villain group known as Helix: the original members are Arak the Wind-Walker, Baby Boom, Kritter, Mister Bones, Penny Dreadful, and Tao Jones.

[9] Infinity, Inc. is involved in the Crisis on Infinite Earths event, which results in three new superheroes—Yolanda Montez as Wildcat, Rick Tyler as Hourman, and Beth Chapel as Doctor Mid-Nite—joining the team.

Northwind returns and leads Infinity, Inc. into a final confrontation with the Silver Scarab at Hall Mansion, which, when burned down, reveals a topless pyramid inside.

During Hector and Lyta Trevor-Hall's wedding, Harlequin (Marcie Cooper) uses trickery to make Bones and Skyman meet at Solomon Grundy's room.

The Earth-2 versions of Silver Scarab, Fury, Jade, and Northwind are members, but their Superman is missing, their Flash is retired, and their Green Lantern (Alan Scott) is dead.

[15] The closest that Infinity, Inc. has come to reforming is when Brainwave (under Mister Mind's thrall), Atom Smasher, Northwind, Nemesis, and Eclipso (who at the time was being controlled by the second Wildcat's cousin Alex Montez), were Black Adam's army in Khandaq.

Black Adam mentions in an internal monologue that he had also thought of recruiting Power Girl for the group to further strengthen the Infinity, Inc.

Dan DiDio revealed at a DC Nation panel in Los Angeles that a new Infinity, Inc. ongoing series would debut in September 2007 with John Henry Irons as the main character.

[25] The first issues focuses on Natasha Irons (formerly Starlight), Erik Strom (formerly Fury), and Gerome McKenna (formerly Nuklon), a year after the end of the Everyman Project.

DeSaad admits he was forced to this course of action because the Everymen, even after turning into metahumans, are undetectable from Darkseid's minions, and they could be a wild card during the planned Final Crisis.

Towards the end of the miniseries, an undercover Miss Martian tips Irons off about their imprisonment in the Terror Titans' headquarters, leading to their release.

In the original pitch for the Infinity, Inc. series, creators Roy Thomas and Jerry Ordway had planned on using a young gay male as a new Harlequin.

In an interview with Alter Ego, Ordway explains: "Northwind is shown—but at his side [...] is a new, young, male Harlequin, who Jerry's notes suggest might become comics' first gay character.