The program was initially hosted by Conor Knighton and later Brett Erlich, with features by Ben Hoffman, Sergio Cilli, Sarah Haskins, Bryan Safi, Erin Gibson, and Ellen Fox.

Stylistically similar to The Daily Show, InfoMania put a comedic spin on various pieces of popular culture in the United States, including outrageous news stories, video games, viral videos, as well as movies and music.

Prior to being produced in a full half-hour format, the show aired in short 3-5 minute installments, usually at the top of the hour.

In September 2010, InfoMania began receiving a noticeable amount of negative feedback from their fanbase via Facebook and Current TV's website.

[1] Current TV eliminated the audience from the show in response to these complaints, but they still refuse to post full episodes to the Internet.