The Informix database has been used in many high transaction rate OLTP applications in the retail, finance, energy and utilities, manufacturing and transportation sectors.

On July 24, 2020, HCL announced OneDB Database Server V1.0.0.0 as a multi-model (relational, object-relational, and dimensional) DBMS based on Informix.

The major enhancements made over previous releases were adding built-in index compression, integration of JSON collections with support for MongoDB JSON drivers into the server, and an enhancement permitting database objects to be partitioned across multiple servers in a cluster or grid (aka sharding).

Heterogeneous clusters are fully supported, and there are several deployment options that are available, including some that provide very high levels of data redundancy and fault tolerance.

It has a long track record of supporting very high transaction rates and providing uptime characteristics needed for mission critical applications such as manufacturing lines and reservation systems.

IBM is offering an inclusive package of Informix materials to college faculty called "Informix In a Box",[17] which offers hands-on labs and PowerPoints to use in lessons, recorded training for teachers, DVDs with class material and VMware virtual appliance images, as well as T-shirts for students.

Users groups remain active[18] in Belgium,[19] Croatia,[20] France, Germany, the United States, and many other countries.