Thirteen towns along the Danube between Günzburg and Regensburg considered that they had been neglected by the Bavarian state parliament when it came to railways.

A deputation travelled to Munich on 20 October 1866 to underline the need for a line to be built by the Royal Bavarian State Railways.

Another problem was the cutting at Unterhausen, which had a length of 1.3 km and a maximum depth of 17 m. At that time, machines were rare.

Maschinenfabrik Augsburg was responsible for building the crossing over the Lech at Rain, which required a railway bridge for the first time.

Very long and high embankments were constructed so that rail operation would not be interrupted even during floods.

Railway construction boosted the demand for labour and foreign workers were hired.

The railway company had already signed a contract with the municipality of Obergrasheim for the purchase of 500,000 cubic metres of peat to be delivered in 1874.

After leaving Seehof, the Ingolstadt–Augsburg railway branches off and the line now continues as a single track to Weichering station, where it returns to the original route from the entry signal.

Due to these additional journeys, the stations of Rain, Burgheim and Weichering are also used for scheduled train crossings.

Since the timetable change on 13 December 2015 the Agilis trains have also been arriving in Ingolstadt Nord from both directions (Donauwörth and Regensburg) from Monday to Friday in order to improve connections to the Audi plant.

A new, modern and disabled-friendly platform was put into operation in Schwenningen at the timetable change on 10 December 2006.

Previously, Schwenningen had a split platform that was divided by the level crossing of the connecting road to Wolpertstetten.

The service to Ulm usually runs hourly, using Alstom Coradia Continental multiple units.

The platform itself was put into operation at the timetable change of December 2012, but the reconstruction of the surroundings had not yet been completed.

The community of Blindheim would have liked to have a bike&ride facility after the actual work on the construction of the platform has been completed, with.

The access points to the side ramp were upgraded when platform 1 in Blindheim was rebuilt in the spring of 2012.

DB Station&Service had already agreed to build the second platform at Tapfheim, provided that a necessary underpass was built by the federal government and the Free State of Bavaria.

In contrast, the overpass that had been planned for more than 10 years was built between Tapfheim and Schwenningen in the summer 2012.

Several collisions between rail and road vehicles had occurred at both level crossings, several involving fatalities.