The Marshal of the Casa da Torre dos Garcia D'Ávila erected a church of the Divine Holy Spirit in Inhambupe in the 1620s.

[4] From 1718, the village was part of the Parish of Água Fria, but on April 24, 1728 Vasco Fernandes Cézar de Menezes elevated Inhambupe to the status of town.

[4] According to local tradition, at the end of the 19th century, the mystic Antônio Conselheiro passed through the city, before the War of Canudos.

Municipal Law No.1 of 20 October 1909 established the districts of Barreiro, Bebedouro, Caetitú, Calumbi, Caueira, Curralinho, Encantado, Gibóia, Jacu, Junco, Lagoa, Mulungu, Recreio and Tanquinho.

[9] The average infant mortality in Inhambupe is 17.24 per 1,000 live births, which is ranked 144th out of 417 municipalities in the state, and 1510th out of 5570 nationwide.