The cartoon shares its name with an earlier short directed by Bob Clampett, which features Porky Pig.
Two scouts spot him and one of them gives chase, only to fall into a chasm when the weight of him and his horse causes the makeshift bridge to collapse.
As Cool Cat drives along, he encounters more Native Americans in the following scenarios: Finally arriving in Hotfoot, Cool Cat spots two horses playing with human shoes, a "Horse Doctor" who really is an equine, and a showdown between two gunslingers that ends with one's belt being shot, causing his pants to drop.
An outlaw named Gower Gulch then arrives and seemingly challenges Cool Cat to a duel, but then settles for a game of poker.
Owing to controversy over its stereotyping of Native Americans (and some racy puns such as "Indian wrestling" with a curvy Native American woman and the "topless saloon", along with the use of the ethnic slur "Injun" and being used as the reel's title), the cartoon has never been shown by U.S. television broadcasters such as Cartoon Network, or released on video.