She attended the University of Paris and graduated in 1967 with a degree in social sciences.
[3] Although Sissoko did not belong to the governing party, Sudanese Union – African Democratic Rally,[4] she was selected as Secretary of State for Social Affairs after the 1968 Malian coup d'état, making her Mali's first female member of government.
[5] Beginning in 1985, she worked as an advisor for the Ministry of Labour and Civil Service (ministère du Travail et de la Fonction publique).
As a result, Moussa Traoré's military government ended the colonial-era ban on contraception; Mali was the first Francophone country in Africa to take this measure.
Sissoko was the first woman named a Grand Officer of the National Order of Mali.