[1] Since its foundation in 1963, it has served as the only institution for selecting and training diplomatic professionals in Argentina.

[3] The ISEN was founded on 10 April 1963, during the presidency of José María Guido, on initiative of Foreign Minister Carlos M. Muñiz.

Discussions on the professionalisation of diplomatic corps (as well as other state officials, in general) had become popular in Argentina and elsewhere since the 1950s.

Throughout the 20th century, Argentina's unstable political climate led to abrupt changes in the institute's curricula and internal norms.

This would change starting in 1971, due in part to protests from undergraduate students of diplomacy degrees from Argentine universities.