[2] During the COVID-19 pandemic in Singapore, IHiS developed several healthtech projects including, the Command, Control, and Communications (C3) System, which was co-developed with Tan Tock Seng Hospital.

In January 2021, GPConnect was adopted and deployed as the national EMR system for Singapore's COVID-19 vaccination operations (VacOps).

[14][15] In 2015, IHiS established the HealthHub, a web portal and mobile application for national health information and services.

Information relating to the names, National Registration Identity Card numbers, addresses, dates of birth, and race and gender of patients who visited specialist outpatient clinics and polyclinics between 1 May 2015 and 4 July 2018 was maliciously accessed and copied.

19 measures were put in place, including two-factor authentication for all administrators, proactive threat hunting and intelligence, allowing only computers with latest security updates on hospital networks, and a new database activity monitoring.