Quebecair grew to become a second-tier regional airline, operating British Aircraft Corporation BAC One-Eleven, Boeing 727-100, Boeing 737-200, and Fokker F28 Fellowship jets, as well as Convair 580, Fairchild F-27, and Hawker Siddeley HS 748 turboprops and other propeller aircraft on routes throughout the province of Quebec, New Brunswick, and elsewhere in eastern Canada.

In the late 1980s, Inter-Canadien rolled over its fleet, becoming the North American launch customer for the Fokker 100 twin jet and the first Canadian operator of the ATR 42 turboprop.

In 1990, Inter-Canadien cancelled its code-share agreement and began competing with Canadian Airlines International and Air Canada on high density routes between Montreal, Ottawa, Toronto, and Halifax.

As a result, Inter-Canadien almost doubled in size, increasing its fleet from ten ATR 42s to 16 ATR propjets and three Fokker F28 Fellowship twin jets operating on a route network that reached from St, John's, Newfoundland, in the east to Sault Ste.

Inter-Canadien suspended flight operations November 27, 1999, concurrent with the collapse of its code-share partner, Canadian Airlines International (which was acquired by Air Canada).