Some authors have alleged the ISI of supporting the 1999 release of Ahmed Omar Saeed Sheikh, who was subsequently convicted of the 2002 beheading of Wall Street Journal reporter Daniel Pearl.

Pasha reportedly adopted a hostile stance on Washington, cutting down the ISI's cooperation, jailing Shakil Afridi, the Pakistani informant who whistleblew Osama bin Laden's alleged presence to the CIA, "ordering the harassment of U.S. diplomats in Pakistan" among other things.

[7] In 2013, Pakistan Tehreek-e-Insaf a political party that also runs the government in the Pakistani North Western province Khyber Pakhtunkhwa lodged a complaint against CIA director John O. Brennan and Islamabad station chief Craig Osth for aiding in the drone attack at Hangu District on 21 November 2013.

[8][9] ISI operative Mohammed Tasleem, an attache in the New York consulate, was found by the FBI in 2010 to be issuing threats against Pakistanis living in the United States, to prevent them from speaking openly about Pakistan's government.

[11] Syed Ghulam Nabi Fai is a Kashmiri American activist who was charged for concealing transfer of USD 3.5 million from the Inter-Services Intelligence (ISI) to fund his lobbying efforts and influence the U.S. government on the Kashmir conflict in violation of the Foreign Agents Registration Act.