The Interamerican Region services Scouting in the Western Hemisphere, both North and South America.

[1] Even today, the Interamerican Region exists more for the benefit of countries south of the Rio Grande, as evidenced by the website being only in Spanish until 2011; consequently, the United States and Canada did not participate as vigorously in regional activities as do other national organizations around the world, however this is changing in the 2010s.

The headquarters of the Interamerican Region moved progressively southward from its inception until 2010, starting in Havana, Cuba, from 1946 to 1960; moving briefly to Kingston, Jamaica, in 1960; immediately relocating to Mexico City, Mexico, between 1960 and 1968; then to San José, Costa Rica, between 1968 and 1992; Santiago, Chile, from 1992 to 2010, most recently relocating to Ciudad del Saber, Panama.

For years there was an active Boy Scouts of the United Nations with several troops at Parkway Village in New York City, with but 14 members in 1959.

Also directly registered to the World Bureau were the 900 member International Boy Scouts of the Canal Zone.