Interceptions are predominantly made by the secondary or (on some occasions) the linebackers, who are usually closest to the quarterback's intended targets: the wide receivers, running backs, and tight ends.
For example, on December 4, 2016, the Kansas City Chiefs strong safety Eric Berry scored the game-winning points via a pick-two in a 29–28 victory over the Atlanta Falcons.
There are also player safety implications: when the ball is turned over, the play is now suddenly and unexpectedly moving in the opposite direction.
Additionally, offensive players, particularly the quarterback, are often inexperienced tacklers and are at risk of injuring themselves while tackling the ball carrier.
Barron Miles, a defensive back in the early 2000s for the BC Lions and Montreal Alouettes, recorded 66 interceptions, tied for second all-time, in a 12-year CFL career.
Larry Highbaugh played for the BC Lions and Edmonton Eskimos during the 1970s and early 1980s, winning six Grey Cups and recording 66 interceptions in his career.
Lester Hayes of the Oakland Raiders was one of the National Football League's (NFL) leaders at interceptions in the late 1970s and early 1980s.
After the NFL outlawed the use of such foreign substances in 1981, Hayes' success rate at interceptions dropped below average though that could be due to his reputation as a "shutdown cornerback", which discouraged opposing teams from throwing to his side of the field.
[3] In the 2009 NFC Championship Game, with his Minnesota Vikings almost within range of a potential game-winning field goal in the last few minutes of regulation, Favre threw an interception to Tracy Porter, and the New Orleans Saints would end up winning in overtime.
Rodney Harrison of the New England Patriots and San Diego Chargers was the first player in NFL history to have 30 interceptions and 30 sacks over the course of his career.
The NFL's Defensive Player of the Year Harrison picked off Kurt Warner's pass and returned it a Super Bowl-record 100 yards for a touchdown on the final play of the first half to give the Pittsburgh Steelers a 17–7 lead over the Arizona Cardinals.
On December 26, 2010, Brady overtook the previous record of 308 consecutive completed passes without an interception, held by Bernie Kosar of the Cleveland Browns since 1991.
On October 6, 2013, Matt Schaub became the first quarterback to throw a "pick-six" (an interception returned for a touchdown) in four consecutive games, while playing against the San Francisco 49ers.
[4] In Super Bowl XLIX, New England Patriots cornerback Malcolm Butler intercepted a would-be go-ahead touchdown pass from Seattle Seahawks quarterback Russell Wilson at the goal line in the final seconds of the game, allowing the Patriots to win what would have been an otherwise near-certain defeat.
[6] Robert Hardwick of the Nottingham Caesars of the BAFA National Leagues scored a game-winning touchdown against the Birmingham Bulls on May 15, 2016.
The Bulls were three points up at the four-yard line with 14 seconds left on the clock, and elected to throw a pass which was intercepted and run 100 yards to the opposite end zone.
Because of the relatively strict offside law in both codes of rugby, and the requirement that all passes be backward, interceptions are difficult to achieve.
However, when they occur, the side who loses possession is suddenly out of formation to defend, and the interceptor may be able to sprint down the field for a spectacular try.