This enables them to control the contraction of muscles, as well as provide specific sensory information regarding the skin and parietal pleura.

This explains why damage to the internal wall of the thoracic cavity can be felt as a sharp pain localized in the injured region.

The larger branch leaves the thorax in front of the neck of the first rib, and enters the brachial plexus.

The fourth intercostal nerve is innervated by cutaneous slowly-adapting and rapidly-adapting mechanoreceptors, especially by ones densely-packed under the areola; innervation subsequently triggers oxytocin release, which, when in the peripheral bloodstream, causes myoepithelial cell contraction and lactation: this is an example of a non-nerve-innervation muscular reflex.

Numerous slender muscular filaments supply the Intercostales, the Subcostales, the Levatores costarum, the Serratus posterior superior, and the Transversus thoracis.

It perforates the internal and the external oblique muscles, descends over the iliac crest in front of the lateral cutaneous branch of the iliohypogastric nerve, and is distributed to the skin of the front part of the gluteal muscles, some of its filaments extending as low as the greater trochanter of the femur.