The Interdisciplinary Science and Engineering Complex (ISEC) is a 234,000 square-foot (21,700 m2)[1] building at Northeastern University designed for collaborative research, laboratory access, and classroom learning.

[4] In the final 2013 version of the document, the complex had been revised to be a three building cluster with an option for a fourth, connected to the main campus by a bridge known as "The Arc".

[10] The building, now referred to in documents as ISEC, officially broke ground in February 2014, with a scheduled completion date in 2016.

[11][12] Suffolk Construction was the primary contractor, with engineering provided by Arup Group and Vanasse Hangen Brustlin.

[19][20][21] The rail corridor that serves Amtrak, the Orange Line, and commuter trains makes walking or biking from one side to the other difficult, effectively isolating Northeastern's main campus from the Roxbury neighborhood.

[34] In May 2019, Northeastern proposed a single second building that would complete the complex, EXP, with plans to begin construction in early 2020.

[35] The 350,000 sq ft new building was anticipated to take three years to complete and includes dynamic research spaces for driverless cars and humanoid robots.

The first floor consists of two 50-seat lecture halls, two 50-seat active learning classrooms, a bicycle storage room, a 24-seat biomaterials teaching lab, a cafe, and a 280-seat auditorium.

Much of the research space which borders this main atrium is completely visible to observers, allowing for high levels of transparency between the public and different disciplines.

[46] The Boston Globe noted that the completion of the ISEC facility was the culmination of a major shift in the culture, history, and trajectory of Northeastern University.