Their main themes are machine learning, data mining, and computational intelligence algorithms applied to biological and biostatistical problems.

[1] During their first editions, the CIBB conferences were organized and attended mainly by Italian researchers at various academic locations throughout Italy.

The conference is a single track meeting that includes invited talks as well as oral and poster presentations of refereed papers.

It usually lasts three days in September, and traditionally includes some special sessions about the application of computational intelligence to specific aspects of biology (for example, the "Special session on machine learning in health informatics and biological systems" at CIBB 2018,[2]) and occasionally some tutorials.

At the 2011 conference edition in Gargnano, the scientific committee gave a young researcher best paper award.