The organization is dedicated to improving the quality of life for all myeloma patients by focusing on four key areas: research, education, support, and advocacy.

US-based seminars have been held in Boca Raton, Florida; Seattle, Washington; Boston, Massachusetts; and Los Angeles, California.

Internationally based seminars have been held in the Czech Republic, Denmark, Germany, France, Austria, Norway, Slovakia and Italy.

[6] The IMF is involved in a variety of research efforts, which include maintaining a myeloma gene and tissue bank project.

The grants are made possible through donations from private individuals and are awarded to doctors and researchers in the field of myeloma, as well as related disorders including but not limited to MGUS (monoclonal gammopathy of undetermined significance) and immunoglobulin derived amyloidosis.

[10] The organization holds its major fundraising event, the annual Comedy Celebration benefiting the Peter Boyle Memorial fund, in November of each year.