International Securities Exchange Holdings, Inc. (ISE) is a wholly owned subsidiary of American multinational financial services corporation Nasdaq, Inc.

Founded in 2000, the ISE was conceived in 1997 when then-chairman of E-Trade, William A. Porter and his colleague, Marty Averbuch approached David Krell and Gary Katz about their concept and the four founded what is today the International Securities Exchange, a leading U.S. equity options exchange.

Launched as the first fully electronic US options exchange, ISE developed a unique market structure for advanced screen-based trading.

In August 2008, ISE Stock Exchange announced a partnership with the electronic communication network Direct Edge.

The deal made the ISE Stock Exchange a wholly owned subsidiary of Direct Edge and gave ISE an ownership stake in Direct Edge.