The museum is located in the former Roslyn Auditorium, a Depression-era brick building built in 1936 with funding from the Works Progress Administration.

Lawrence Diggs, a resident who had lived in the town since 1989, had extensive knowledge of vinegar and a small collection from his time researching the substance at San Francisco State University.

[4] There is also a small gift shop that sells vinegar-themed merchandise and the museum's own line of vinegars, including flavored varieties and a balsamic imported from Italy.

[4] Built in 1936 by the Works Progress Administration (WPA), the Roslyn Auditorium became a center of social life in a developing small, rural community.

Roslyn is a small settlement in rural northeast South Dakota, founded in the path of the Soo Line Railroad, and its main industry is agriculture.

It has acted as a multipurpose building across the decades and has seen use as a gymnasium, performance hall, social club, and a senior citizens' center before becoming the International Vinegar Museum.

The building was listed on the National Register of Historic Places on February 9, 2001, deemed significant for its local notability and as a product of the WPA.