Near the former site of the Greendale Mall, there is an interchange with Route 12 before the highway passes along the eastern shore of Indian Lake and continues through the northern points of Worcester.

The freeway later crosses the Quinapoxet River and then curves to the northeast reentering West Boylston.

North of Johnny Appleseed State Park and Lancaster Town Forest, I-190 reaches its northern terminus at Route 2 and Mechanic Street in the city of Leominster.

[2] A portion of the highway was built with extra-wide shoulders, which are painted green, to prevent runoff from contaminating the nearby Wachusett Reservoir.

[3] All interchanges were to be renumbered to mileage-based numbers under a project scheduled to start in 2016.