It runs for 1.67 miles (2.69 km) from the intersection of Commonwealth Avenue (SR 381) and Keys/Church streets in Bristol at exit 0 north to I-81.

The roadway continues south as US 11E and US 19 following Volunteer Parkway, a major arterial through Bristol, Tennessee, that leads toward Johnson City.

Westbound Euclid Avenue heads west carrying northbound US 421 and southbound US 11W toward Kingsport and Gate City.

SR 381 continues north along Commonwealth Avenue, paralleling a railroad line through an industrial area to its northern terminus at an intersection with Keys Street.

I-381 runs for 1.67 miles (2.69 km) from the intersection of Commonwealth Avenue (SR 381) and Keys/Church streets in Bristol at exit 0 north to I-81.