Traveling southeast through rural Belmont County, I-470 approaches the Vietnam Veterans Memorial Bridge, which spans the Ohio River.

The three-level diamond interchange with concurrent highways U.S. Route 250 (US 250) and West Virginia Route 2 (WV 2) on the eastern banks of the Ohio River was thought to be the most complex interchange in West Virginia's Interstate Highway System at the time of construction.

[2] High Ridge Road, to the north, connects back to I-70 and, to the south, links Bellaire to the bypass.

[5][6] The American Automobile Association considers the stretch of I-470 though Ohio to be a scenic highway due to its natural beauty.

Continuing easterly, I-470 comes to its end at an incomplete interchange with its parent, I-70,[10] over Wheeling Creek near Elm Grove and to the north of the J.B.

[16][17] Plans for a southern bypass of Wheeling were first published in 1955 in Bureau of Public Roads document titled General Location of National System of Interstate Highways Including All Additional Routes at Urban Areas.

[18] An environmental impact statement was filed in 1972 by West Virginia, detailing the I-470 interchange with US 250/WV 2 along the eastern banks of the Ohio River.

[31] Between September 12 and December 22, 1996,[32] about 1,700 feet (518 m) of I-470 in Ohio was closed so ODOT could stabilize and repave the roadway, as the rocks forming the top of an abandoned mine underneath the freeway had become overstressed.

[35] The Wheeling Tunnel was closed for reconstruction work in 2007,[36] 2008,[37] and 2010,[38] causing motorists who wished to travel through on I-70 to detour.