I-90 enters Pennsylvania from Ohio in Springfield Township, Erie County, heading east as a four-lane freeway through rural areas of fields and woods.

The highway passes through more rural areas with some nearby development and reaches a cloverleaf interchange with I-79, which provides access to the city of Erie to the north.

[2][3] A short distance past I-79, the freeway enters Summit Township and heads northeast to an interchange with US 19 in a commercial area.

I-90 runs through wooded areas with nearby suburban development and comes to the PA 97 interchange near Presque Isle Downs & Casino.

The freeway heads back into rural areas of farms and woods, coming to the PA 531 exit.

[6][7] In 2007, a major pileup forced a 15-hour closure of the entire stretch of I-90 in Pennsylvania due to winter storm whiteout conditions.