The bay is located in the northern part of Upernavik Archipelago, between Kiatassuaq Island in the north and Nuussuaq Peninsula in the south.
At its widest − from the Wilcox Head promontory on Kiatassuaq Island to the Tinumanersuaq cape on Nuussuaq Peninsula[1] − Inussulik Bay stretches for 43.12 km (26.79 mi).
[1] Nuussuaq Peninsula defines the southern and southeastern limit of Inussulik Bay.
The farthest inlet of the bay is choked with icebergs calving off the Illullip Sermia glacier.
[1] Kangerluarsuk Fjord is the main inlet of Inussulik Bay in the south; one of several of that name in Greenland.