[1] Inverleith House was designed in 1773 by David Henderson and built for James Rocheid in 1774.

[2][3] In about 1820 a part of the Inverleith estate was sold to become the Royal Botanic Garden.

The house was bought by the city in 1877 together with another part of the estate and, after restoration work following a fire,[2] became the official residence of the Regius Keeper (director) of the Royal Botanic Garden.

From 1960 it housed the new Scottish National Gallery of Modern Art, which in 1984 moved to the building of the former John Watson's Institution on Belford Road.

[2] Since 1986 the house has been used as exhibition space by the Royal Botanic Garden.