Alix Spiegel was a founding producer of This American Life and freelanced for NPR's Science Desk covering psychology and human behavior.

[4] At Chicago's Third Coast International Audio Festival, Spiegel met former Radiolab producer Lulu Miller and asked her to co-produce a piece she was working on.

The show's first six-episode season aired from January to February 2015, with excerpts occasionally running on All Things Considered, Morning Edition, Radiolab and This American Life.

This extra exposure and Miller and Spiegel's track record helped Invisibilia debut at #1 on the iTunes podcast chart and to maintain a consistent top-ten ranking in the months following its launch.

[8] In June 2020, NPR announced that Spiegel and Rosin would relinquish their roles by early 2021, and Kia Miakka Natisse and Yowei Shaw were named the new co-hosts of the program, which aired its seventh season in April 2021.