[1] It was established in 1859, making it the oldest formal educational institution in Zimbabwe.

[2][3] Along with Dombodema High School in Plumtree[4] and Tennyson Hlabangane High School (formerly Hope Fountain Mission) in Bulawayo,[5][6] Inyathi High School is privately owned by the United Congregational Church of Southern Africa (UCCSA) which is itself an offshoot of the London Missionary Society (LMS).

[citation needed] Welfare management of students is by a rigid traditional four house system.

The houses are named after the school's founders and assigned colours as follows: Accommodation arrangements in the dormitories and sitting arrangements in the dining hall are based strictly on the School House System.

[citation needed] Inyathi students compete with other Bubi District secondary schools, including Somvubu, Gloag, Majiji, Sijawuke, Dabenga, Mangubeni, and Siganda High Schools.