Ion interaction chromatography

In this technique ions are mixed with ion pairing reagents (IPR).

[1] The analyte combines with its reciprocal ion in the IPR, this corresponds to retention time.

Often organic salts are selected to pair with solute(s).

The formation of this pair affects the interaction of the pair with the mobile phase and the stationary phase.

[2] This article related to chromatography is a stub.

Oppositely charged particles interact as they are moved through a column. While paired there is more tendency to flow through the column, in reverse phase chromatography.