Ionikos Nikaias' men's basketball club was founded in 1965, and it played its first game in 1966, during the 1966–67 season.

Over the years, the club has featured Greek players such as: Panagiotis Giannakis, Fotis Katsikaris, Nikos Oikonomou, Vangelis Margaritis, Vassilis Kavvadas, and Marios Batis.

The club also competed in the 3rd-tier level European-wide competition, the FIBA Korać Cup, in both the 1979–80 and 1984–85 seasons.

In order to complete the transfer, Giannakis also personally received a BMW car, a sporting goods store, and 8 million drachmas from Aris.

[3] Ionikos' long-time home arena (1970–2018, 2020–present) is the Nikaias Platonas Indoor Hall (Greek: Κλειστό Γυμναστήριο Πλάτων Νικαίας), which is an indoor arena that is located in Nikaia, Piraeus, Athens, and has a seating capacity of 1,200 people.

For the Greek Basket League 2019–20 season, while the arena was being renovated, Ionikos moved into the Sofia Befon Indoor Hall,[4][5] which is located in Palaio Faliro, Piraeus, Athens, and has a seating capacity of 1,204 people.