Seven miles (11 km) east of the I-35 interchange, Iowa 105 entered Northwood along Central Avenue.

US 65 and Iowa 105 overlapped each other for two blocks, ending at Sixth Street, when US 65 turned south again.

One mile (1.6 km) east of Carpenter, Iowa 105 intersected Mitchell County Road S70, which travels 6 miles (9.7 km) north and connects to Minnesota State Highway 105.

[5] East of the intersection with CR S70, the highway traveled southeast towards St. Ansgar.

Iowa 105 crossed a Canadian National Railway line before ending at U.S. Route 218 just 100 yards (91 m) later.