It begins in Tipton at Iowa 38 and ends at Interstate 80 (I-80) / U.S. Highway 61 (US 61) in Davenport.

It proceeds eastward from Tipton and shortly before Bennett, it turns south to enter town.

It continues southeast through Plainview and Maysville and ends at exit 292 along Interstate 80 in Davenport.

By the 1980s, a portion of Harrison and Brady Streets had become one-way streets, joining near Vander Veer Park, leading to Iowa 130 to be truncated at the park.

[3] When Welcome Way was completed in 1983 and southbound traffic was moved onto Harrison Street, Iowa 130 was truncated further back to Interstate 80.