The routing closely parallels and crosses the former Chicago, Milwaukee, St. Paul and Pacific Railroad grade.

The route crosses the meandering Des Moines River next to the former Milwaukee Road high bridge[2] before entering Madrid.

Iowa Highway 210 continues east and enters Story County and the town of Slater.

[3] East of Interstate 35, Iowa Highway 210 primarily serves local traffic.

The route crossed the Des Moines River next to the Milwaukee Road high bridge[2] before entering Madrid.