The program began in 1895 and has fielded a team every year since with the exceptions of 1906–1907 and 1943–1944.

[5] The Panthers have reached the NCAA Division I Football Championship playoffs 22 times, with a record of 24–22.

The UNI-Dome opened in 1976, as the home of the UNI Panthers football team.

The announcers will announce the weather in the town where the visiting team is from, the current weather conditions outside the Dome, and then say "Inside - 72 degrees, no wind, welcome to the Dome!"

[7] First Team Selections [8][9][10][11][12] WR=Williamson Ratings; AP=Associated Press; c - 2020-21 selections include players who played Fall 2020 and teams (such as Northern Iowa) which moved their schedule to Spring 2021 due to COVID