[1][2] Former Iranian Prime Minister, Mohammad Mosaddegh obtained his Doctorate of Laws (doctorat en droit) at the University of Neuchâtel in Switzerland, 1911.

As a child, Mohammad Reza Pahlavi, the Shah of Iran attended Institut Le Rosey, a Swiss boarding school, completing his studies there in 1935.

[3] Beginning in 1984, victims of the Iran–Iraq War received medical treatment in neutral Switzerland, while Swiss companies were doing multibillion-dollar business with Iraq at the same time.

Ali Fallahian, an Iranian politician and cleric who served as a member of the 3rd Assembly of Experts of the IRI and as the Minister of Intelligence of Islamic Republic of Iran in cabinet of President Hashemi Rafsanjani was charged by a Swiss court[4][5] with masterminding the assassination of Kazem Rajavi, a brother of Mujahedin-e Khalq leader Massoud Rajavi, near Geneva in broad daylight by several agents on April 24, 1990.

Swiss media and the German magazine Der Spiegel took up his case in 1994, pursuing the question of whether Crypto's machines had in fact been rigged by Western intelligence (namely the NSA).

[12] Friedrich Tinner is a Swiss engineer, connected with the Khan network trafficking in the proliferation of nuclear materials and know-how to Pakistan, Iran, Libya, and North Korea.

A number of crucial agreements such as the JCPOA in 2015 but particularly direct affairs such as the exchange of U.S. and Iranian detainees in 2023 were negotiated through the Swiss protecting power mandate.

Earlier, U.S. Secretary of State Antony Blinken met with the Gulf Cooperation Council (GCC) Secretary General Jasem Mohamed AlBudaiwi and GCC member states' foreign ministers in New York and issued a joint statement that included a warning to Iran “to cease its proliferation of dangerous weapons that pose a grave security threat to the region".

[23] In the aftermath of the Israeli airstrike on the Iranian consulate in Damascus in April 2024, the U.S. indirectly communicated with Iran through the Swiss intermediary about the imminent attack on Israel.

[26] Marking 100 years of high-level diplomatic ties, Swiss president Ignazio Cassis made an official visit to Iran from 5 to 7 September 2020.

Mr Cassis‘ encounter with Iranian President Hassan Rouhani, Foreign Minister Mohammad Javad Zarif and Secretary of the Supreme National Security Council Ali Shamkhani underscored the successful bilateral ties and continued presence of Swiss companies and institutions in Iran.

Swiss officials were introduced to the new speaker of the Iranian Parliament Mohammad Bagher Qalibaf, reflecting the excellent cooperation between the two nations.

In January 2025, Iranian state media reported that a Swiss national had died in captivity in Iran after being held on espionage charges.

[30][31] There are agreements between the two countries on air traffic (1954, 1972 and 2004), road and rail transport (1977), export risk guarantees (1966), protection of investments (1998) and double taxation (2002).

[44] The Swiss government has been cooperating with the U.S. to freeze banking accounts and other financial assets belonging to individuals involved in the Iranian nuclear program; Switzerland has also committed to block the sale of dual-use items.

[48] The adoption of the Joint Comprehensive Plan of Action (JCPOA) took place in the Swiss city of Geneva and the general framework of the current agreement was concluded on April 2, 2015 in Lausanne.

On 15 June 2021, Swiss Foreign Minister Ignazio Cassis and US president Joe Biden said during a press interview in Geneva, Switzerland, they would both support more payments through the rarely used Swiss-Iranian humanitarian channel.