Irena is a village in north central Worth County, Missouri, United States.

[5] According to the United States Census Bureau, the village has a total area of 0.88 square miles (2.28 km2), all land.

[7] A post office called Irena was established in 1883, and remained in operation until 1932.

[8] As of the census[10] of 2010, there were 18 people, 7 households, and 5 families residing in the village.

As of the census[3] of 2000, there were 33 people, 9 households, and 9 families residing in the village.

No households were made up of individuals, and none had someone living alone who was 65 years of age or older.