[1][4][3]Iridocorneal Endothelial (ICE) syndrome presents a unique set of challenges for both patients and ophthalmologists, and effective treatment of this group of rare ocular diseases requires a combination of diagnostic and therapeutic complexity.

[1] Many cases are asymptomatic, however patients many have decreased vision, glare, monocular diplopia or polyopia, and noticeable iris changes.

[1] Herpesvirus DNA has been identified in some patients following keratoplasty, suggesting the possibility that herpes simplex virus may induce the abnormal endothelialization in the anterior chamber angle and on the surface of the iris.

[2][4][6] The Chandler variant of ICE is characterized by pathology on the inner surface of the cornea leading to abnormal endothelial pump function.

[2][5] Other features include possible mild iris changes, corneal edema, and normal to slight elevations in intraocular pressure.