[1] The ODI series formed part of the inaugural 2020–2023 ICC Cricket World Cup Super League.

[5] Prior to the series, the Irish team were scheduled to play five white ball matches against the United States in Florida.

[7][8] The second ODI, originally scheduled to be played on 11 January 2022, was postponed after Ireland captain Andrew Balbirnie, wicket-keeper Lorcan Tucker and interim head coach David Ripley tested positive for COVID-19.

[11] Ahead of the ODI series, Ireland played a 50-over tour match against Jamaica, losing the fixture by five wickets.

[24] Simi Singh and Ben White were both ruled out of Ireland's squad for the first ODI after providing positive COVID-19 tests.