Iron–platinum nanoparticle

[1] Currently there are many synthetic methods such as water-in-oil microemulsion, one-step thermal synthesis with metal precursors, and exchanged-coupled assembly for making FePt NPs.

[11] The black precipitates are then washed and dried on silicon substrates to be characterized by transmission electron microscopy (TEM) and X-ray diffraction.

[14] Due to their superparamagnetism and controllable shape, size, and surface, iron-platinum nanoparticles have great potential for advancing medicine in many fields, including imaging, pathogen detection, and targeted cancer therapy.

[15] FePt NPs also provide a non-toxic, more persistent alternative to iodinated molecules that are harmful to the kidney and survive in the body for only a short time.

[4] The superparamagnetic properties of the nanoparticles and the systematic method for conjugating ligands to the FePt surface makes them viable vehicles for detection of pathogens such as gram-positive bacteria.

By attaching peptides to the surface of the face-centered cubic FePt NPs, cytotoxic iron can be delivered to specific locations and taken up with high selectivity.

Fe catalyzed decomposition of hydrogen peroxide into ROSs results in membrane lipid oxidation, damage to DNA and proteins, and tumor death.