The Iron Spider armor first appeared in The Amazing Spider-Man #529 and was designed by Joe Quesada, based on a sketch by Chris Bachalo.

After being revived from a battle with Morlun, Tony Stark created the Iron Spider Armor as a gift to Peter Parker, in order to get the young hero's support for the Superhero Registration Act.

But during several fights, Parker slowly became disturbed over the battles with several unregistered heroes, and discovered that Stark was using the suit to monitor him, along with several devices in play to incapacitate him if necessary.

But during a trip to 42, a prison that illegally held super-powered individuals within the Negative Zone without trial or counsel, Parker became completely disgusted with Stark's actions, and turned his back from the Registation's side of the war, and forgone the costume after "reformed" criminals Jester and Jack O' Lantern attacked his aunt and wife in an attempt to capture him, and after a serious confrontation with Stark, leading the tech genius to repossess it.

She uses her experience in Iron Man's suit and her brief spider powers that she had back in the Spider-Island storyline to operate the armor.

Stark describes them as too delicate to use in combat, yet Spider-Man shortly afterward uses them to smash through the sensors in Titanium Man's helmet.